Schrader has gray hair, a beard and a mustache. His eyes are black and he wears a brown waistcoat and matching trousers. He wears a white shirt with a blue spotted tie underneath and a dark brown jacket, a matching hat and plain shoes. He also has glasses that he is seen wearing in Eternal Diva.
Schrader is a kind man and an archaeologist who loves researching historical landmarks. He cares a lot for Professor Layton and they are close friends.
As he, Layton and Emmy are headed to the theater, Luke reads that Schrader contributed to the construction of the Crown Petone in The Eternal Kingdom program.
He only briefly appears in the movie. He conducts research about Ambrosia with Emmy at his flat. They both watch the arrival of the submarine holding the 'losers' of the game for Eternal Life on television before Emmy leaves in a hurry.
In the beginning of the game, Schrader sends Layton a letter:
My dear Hershel,
Knowing you, I imagine you've already heard of the relic known as the Elysian Box. This strange antique is infamous for killing anyone who opens it. Truth be told, I am a bit dubious of the box's murderous reputation. But you know how I am. Once something piques my interest, I simply must get to the bottom of it.
That's why I'm pleased as punch to tell you that the elusive item is finally in my possession. What's more, I believe I'm on the cusp of unraveling a great mystery tied to this box. For the moment, let's just say I have a theory, though I haven't been able to prove it yet.
Initially, it was my intention to finish my research before daring to open its lid. But I must confess that my curiosity is simply overpowering. In the unlikely event that anything should happen to me, please finish the work I've started here.
The letter was sent three days before, so Layton and Luke decide to go to Schrader's flat in London. They arrive to find Schrader on the floor, dead, and the box gone. Layton finds an expired ticket for the Molentary Express, and warns Luke not to say a word about it. They ring the police, and by chance, Inspector Chelmey and his assistant Barton arrive. After initial confusion, they discuss possible reasons for Schrader's death. Chelmey puts it down to natural causes, but Layton and Luke both prove that he was murdered. When Layton finds a torn photo in Schrader's hands, Chelmey gets agitated, takes the photo, and forces them to leave the room.
It was assumed that the Elysian Box had killed Schrader. However, at the end of Diabolical Box, it is revealed that the Elysian Box had only put Schrader in a deep coma, and he recovered a few days afterward in hospital. In the credits, Layton, Luke and Flora are seen reading a newspaper article about his recovery.
In Unwound Future, while Layton and Luke are in Future London, they visit Green Hospital, which now houses an ill and elderly Schrader. Layton later realised that this Schrader was in fact Don Paolo in disguise as he failed to acknowledge younger Luke's presence in the future.
Andrew Schrader, in Unwound Future, gives Layton and Luke one puzzle. This puzzle is "Medicine Time." The X-ray in his room also gives a puzzle. This puzzle is "X-ray Vision."
Professor Layton with Dr. Schrader touring Ambrosia
The Elysian Box can be seen on a desk in Schrader's flat in Eternal Diva.
During the credits of Eternal Diva, he is seen with Layton exploring Ambrosia.
Ewan mentions that Schrader had an assistant called 'Triton' who helped him excavate the museum's fossils. This is likely to be a reference to Luke's father Clark, who studied under Schrader alongside Layton and worked in archaeology before moving to Misthallery
Schrader (or rather the German variant, Schröder) means "tailor".
After opening the box, the doctor falls into a coma so deep that even the inspector believes him to be deceased. Luckily, this proves not to be the case, and his subsquent recovery is sure to be documented in medical journals for years to come.
Dr. Andrew Schrader is Professor Layton's and Don Paolo's old teacher. He is a highly respected archaeologist but has a tendency to get himself into trouble and often needs to be rescued by his students. His collection of antiques is legendary.